Eccentric Los Angeles weatherman and roller skate enthusiast Harris Telemacher (Steve Martin, who also provides the script) is generally happy with his life, although his relationship with style-obsessed girlfriend Trudi (Marilu Henner) could be better. Then one day a message from a freeway sign changes Harris's life, as he begins to find himself attracted to eccentric English photographer Sara (Victoria Tennant - at the time Martin's wife in real life) while simultaneously embarking on a lighthearted romance with flirtatious younger woman SanDeE (Sarah Jessica Parker).

Fletch (Chevy Chase), a reporter with a habit of assuming different disguises, flies to the enormous Louisiana home left to him in a will, only to find it a ruin. Before he can leave, a woman drops dead and he becomes embroiled in a murder mystery. Sequel to the 1985 original.